(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid

CAS No.：547-98-8

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Basic information

Product Name:	(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid
Synonyms:	(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid;3α,7α,12α-Trihydroxy-5β-cholestan-26-oic acid;3α,7α,12α-Trihydroxy-5β-cholestan-27-oic acid;3α,7α,12α-Trihydroxy-5β-cholestanoic acid;3α,7α,12α-Trihydroxycoprostanoic acid;THCA;Trihydroxycholestanoic acid;3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid
CAS:	547-98-8
MF:	C27H46O5
MW:	450.65
EINECS:
Product Categories:
Mol File:	547-98-8.mol

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Chemical Properties

storage temp.	-20°C
solubility	Chloroform (Slightly, Heated), DMSO (Slightly), Ethanol (Slightly), Methanol (Sl
form	Solid
color	White to Off-White

Safety Information

MSDS Information

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Usage And Synthesis

Uses	3α,7α,12α-Trihydroxycoprostanic Acid is a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α,12α-Trihydroxycoprostanic Acid.
Definition	ChEBI: A steroid acid that is 5beta-cholestan-26-oic acid which is substituted by hydroxy groups as the 3alpha, 7alpha, and 12alpha positions.
General Description	Trihydroxycholestanoic acid (THCA) is an oxidative metabolite of cholesterol and a precursor to bile acids. Very long-chain acyl-CoA synthetase (VLCS) associated with endoplasmic reticulum and peroxisomes activates THCA, the C27 bile acid intermediate.
Biochem/physiol Actions	Trihydroxycholestanoic acid (THCA) and dihydroxycholestanoic (DHCA) accumulation is observed in Zellweger syndrome and cholestatic liver disease. The synthesis of (25R)-isomer of DHCA and THCA is favored by mitochondrial 27-hydroxylase.

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Preparation Products And Raw materials

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873