Other grades of this product :
| Shikalkin Basic information |
| Product Name: | Shikalkin | | Synonyms: | 5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene-1,4-dione;SHIKALKIN;1,4-Naphthalenedione, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)- (9ci);Arnebin-4;Nsc 291845;shiconin;Shikonin (mixture of optical isomers, about 1:1);1,4-Naphthalenedione, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-penten-1-yl)- | | CAS: | 54952-43-1 | | MF: | C16H16O5 | | MW: | 288.3 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 54952-43-1.mol |
| Shikalkin Chemical Properties |
| Melting point | 144-145 °C | | Boiling point | 567.4±50.0 °C(Predicted) | | density | 1.373±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | methanol: soluble1mg/mL | | form | powder or solid | | pka | 7.34±0.20(Predicted) | | color | red to brown |
| Hazard Codes | Xn,N | | Risk Statements | 22-50/53 | | Safety Statements | 61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 |
| Shikalkin Usage And Synthesis |
| Uses | Shikonin has been used:- to enhance the anti-tumor activity of gefitinib on tyrosine kinase receptor epidermal growth factor receptor (EGFR) in wild-type lung cancer cells
- as an inhibitor of renal aerobic glycosis and a potential
- as an anti-inflammatory agent to test its role to improve lipopolysaccharide (LPS)-induced cardiac dysfunction
- to stimulate bone marrow-derived macrophages (BMDMs) to test the effect of Interferon regulatory factor 1 on cell death
| | General Description | Shikonin is a major phytochemical compound extracted from the roots of Lithospermum erythrorhizon. It is a natural anthraquinone derivative. | | Biochem/physiol Actions | Shikonin is a potent anti-fungal agent against C. albicans biofilms. It displays anti-oxidant and chemotherapeutic properties on human glioma cells. |
| Shikalkin Preparation Products And Raw materials |
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