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| 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Basic information |
| 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | solid | | color | white to off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Usage And Synthesis |
| Description | AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 μM, human and mouse, respectively). It has minimal effect on TRPV1-4 or TRPM8. AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro. | | Uses | AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice | | Uses | AP-18 is a channel blocker that inhibits TRPA1. | | Biological Activity | Reversible TRPA1 channel blocker (IC 50 values are 3.1 and 4.5 μ M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo . Also blocks TRPA1 pore dilation (IC 50 = 10.3 μM for the inhibition of Yo-Pro uptake). | | Biochem/physiol Actions | AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice. | | in vivo | ap-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. this product is also capable to induce cinnamaldehyde-induced nociception and to block cold- and mustard oil-induced activation of mouse trpa1 but not capsaicin-induced activation 2. in addition, ap18 treatment reversed cfa-induced mechanical hyperalgesia in mice 2. thus, trpa1 is essential for sensitization of nociception. | | References | References”Citations: |
| 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Preparation Products And Raw materials |
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