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| TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) Basic information |
| Product Name: | TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) | | Synonyms: | TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01);T16Ainh-A01;2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide;TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem;Acetamide, 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-;inhibitor of TMEM16A;2-((5-Ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide | | CAS: | 552309-42-9 | | MF: | C19H20N4O3S2 | | MW: | 416.52 | | EINECS: | | Product Categories: | | Mol File: | 552309-42-9.mol |
| TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) Chemical Properties |
| Melting point | 211-212°C (dec.) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | pka | 7.20±0.50(Predicted) | | form | powder | | color | white to beige |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) Usage And Synthesis |
| Uses | TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) compound functions as a selective class A inhibitor of the calcium activated chloride channel TMEM16A. Useful in the treatment of hypertension, pain, diarrhea and mucus overproduction.
| | Uses | This compound functions as a selective class A inhibitor of the calcium activated chloride channel TMEM16A. Useful in the treatment of hypertension, pain, diarrhea and mucus overproduction. | | Uses | T16Ainh-A01 has been used as an inhibitor of transmembrane protein 16A (TMEM16A). | | General Description | An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 μM). Fully blocks CaCC current in salivary gland cells at 10 μM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 μM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels. | | Biochem/physiol Actions | T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance. |
| TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) Preparation Products And Raw materials |
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