(R)-(+)-WARFARIN

CAS No.：5543-58-8

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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(R)-(+)-WARFARIN Basic information

Product Name:	(R)-(+)-WARFARIN
Synonyms:	4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one;(R)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone;(S)-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin;r-(+)-3-acetonybenzyl)-4-hydroxycoumarin;2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (R)-;2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]- (9CI);Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, R-(+)- (8CI);Dextrowarfarin
CAS:	5543-58-8
MF:	C19H16O4
MW:	308.33
EINECS:	226-908-9
Product Categories:	Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	5543-58-8.mol

(R)-(+)-WARFARIN Chemical Properties

Melting point	≥170 °C
Boiling point	515.2±50.0 °C(Predicted)
density	1.307±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF: soluble
pka	4.50±1.00(Predicted)
color	white to pale yellow

Safety Information

Hazard Codes	T
Risk Statements	61-48/25-52/53
Safety Statements	53-45-61
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3

MSDS Information

Provider	Language
SigmaAldrich	English

(R)-(+)-WARFARIN Usage And Synthesis

Chemical Properties	White Solid
Uses	(R)-(+)-warfarin has been used to investigate whether enantiomers of warfarin stereoselectively interact with pregnane X nuclear receptor (PXR) to upregulate main drug/xenobiotic-metabolizing enzymes cytochrome P450 3A4 (CYP3A4) and cytochrome P450 2C9 (CYP2C9). It has also been used in HepG2 cells to study protein profiles
Uses	The R-(+)-form of Warfarin (W498500). Coumarin anticoagulant.
General Description	The chiral carbon at position 9 produces two enantiomers, R- and S-warfarin. Commercially available warfarin (Coumadin or Jantoven) is a racemic mixture of S- and R-enantiomers.
Biochem/physiol Actions	Warfarin acts as a vitamin K antagonist. It is widely used to treat thromboembolic disorders. (R)-warfarin interacts with pregnane X receptor (PXR) and induces cytochrome P450 3A4 (CYP3A4) and CYP2C9 mRNAs expression in primary human hepatocyte cultures.

(R)-(+)-WARFARIN Preparation Products And Raw materials

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