Other grades of this product :
| (R)-(+)-WARFARIN Basic information |
| Product Name: | (R)-(+)-WARFARIN | | Synonyms: | 4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one;(R)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone;(S)-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin;r-(+)-3-acetonybenzyl)-4-hydroxycoumarin;2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (R)-;2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]- (9CI);Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, R-(+)- (8CI);Dextrowarfarin | | CAS: | 5543-58-8 | | MF: | C19H16O4 | | MW: | 308.33 | | EINECS: | 226-908-9 | | Product Categories: | Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 5543-58-8.mol |
| (R)-(+)-WARFARIN Chemical Properties |
| Melting point | ≥170 °C | | Boiling point | 515.2±50.0 °C(Predicted) | | density | 1.307±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: soluble | | pka | 4.50±1.00(Predicted) | | color | white to pale yellow |
| (R)-(+)-WARFARIN Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | (R)-(+)-warfarin has been used to investigate whether enantiomers of warfarin stereoselectively interact with pregnane X nuclear receptor (PXR) to upregulate main drug/xenobiotic-metabolizing enzymes cytochrome P450 3A4 (CYP3A4) and cytochrome P450 2C9 (CYP2C9). It has also been used in HepG2 cells to study protein profiles | | Uses | The R-(+)-form of Warfarin (W498500). Coumarin anticoagulant. | | General Description | The chiral carbon at position 9 produces two enantiomers, R- and S-warfarin. Commercially available warfarin (Coumadin or Jantoven) is a racemic mixture of S- and R-enantiomers. | | Biochem/physiol Actions | Warfarin acts as a vitamin K antagonist. It is widely used to treat thromboembolic disorders. (R)-warfarin interacts with pregnane X receptor (PXR) and induces cytochrome P450 3A4 (CYP3A4) and CYP2C9 mRNAs expression in primary human hepatocyte cultures. |
| (R)-(+)-WARFARIN Preparation Products And Raw materials |
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