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| Coelenterazine Basic information |
| Product Name: | Coelenterazine | | Synonyms: | 8-BENZYL-2-(4-HYDROXYBENZYL)-6-(4-HYDROXYPHENYL)IMIDAZO[1,2-A]PYRAZIN-3(7H)-ONE;2-[(4-HYDROXYPHENYL)METHYL]-6-(4-HYDROXYPHENYL)-8-(PHENYLMETHYL)-IMDAZO[1,2-A]PYRAZIN-3-(7H)-ONE;Coelenteramine
2-[(4-Hydroxyphenyl)methyl]-6-(4-hydroxyphenyl)-8-(phenylmethyl)-imdazo[1,2-a]pyrazin-3-(7H)-one;Imidazo[1,2-a]pyrazin-3(7H)-one,6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-;Oplophorus luciferin;2-(p-Hydroxybenzyl)-6-(p-hydroxyphenyl)-8-benzyl-imidazo[1,2-a]pyrazin-3-(7 H)-one;Coelenterazin;Luciferin (oplophorus) | | CAS: | 55779-48-1 | | MF: | C26H21N3O3 | | MW: | 423.46 | | EINECS: | | Product Categories: | Fluorescent Labels and Indicators;Fluorescent Labels & Indicators;Imidazo[1,2-a]pyrazin-3(7H)-one;Heterocycle;API | | Mol File: | 55779-48-1.mol |
| Coelenterazine Chemical Properties |
| Melting point | 176–181 ℃ (decompose) | | Boiling point | 641.4±65.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | methanol and ethanol: soluble | | pka | 9.91±0.15(Predicted) | | form | solid | | color | yellow | | Sensitive | Moisture & Light Sensitive | | λmax | 429nm | | Biological Applications | Calciumindicator; detecting luciferase,protease,gene expression,nucleic acids,proteins,stem cells,quantum dot conjugates,superoxide; tracing protein dynamics; as a substrate for luciferase,alka | | InChIKey | YHIPILPTUVMWQT-UHFFFAOYSA-N | | CAS DataBase Reference | 55779-48-1(CAS DataBase Reference) |
| Coelenterazine Usage And Synthesis |
| Chemical Properties | Yellow Solid | | Uses | Coelenterazine, native was used:-- For Aequorin assays
- For measuring the intracellular calcium concentration in response to ionomycin or PMA using aequorin in COS-7 cells
- In Bioluminescence imaging for analysing the presence of virus-dependent luciferase activity
| | Uses | Coelenterazine is a luminophore of the aequorin complex which is oxidized by oxygen to illuminate at 465nm when Ca2+ binds to the complex. Used to measure Ca2+ concentration in cells with high sensitivity an dlarge dynamic range.
| | Definition | ChEBI: An imidazopyrazine that is imidazo[1,2-a]pyrazin-3(7H)-one in which positions 2, 6, and 8 are substituted by 4-hydroxybenzyl, 4-hydroxyphenyl, and benzyl groups, respectively. | | General Description | Coelenterazine is a luciferin molecule, which is utilized by several luciferases, such as Renilla,?Oplophorus and?Periphylla. | | Biochem/physiol Actions | Luminophore of the aequorin complex which is oxidized by oxygen to illuminate at 465 nm when Ca2+ binds to the complex; used to measure Ca2+ concentration in cells with high sensitivity and large dynamic range. |
| Coelenterazine Preparation Products And Raw materials |
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