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| IONOMYCIN CALCIUM SALT Basic information |
| Product Name: | IONOMYCIN CALCIUM SALT | | Synonyms: | Calcium ionomycin.;Ionomycin Ca2+ Salt;Ionomycin Ca2+ salt;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacidcalciumsalt;Ionomycin, Calcium Salt, Streptomyces conglobatus - CAS 56092-82-1 - Calbiochem;IONOMYCIN CALCIUM (SQ23377 CALCIUM);ATCC 31005;IONOMYCIN (CA) | | CAS: | 56092-82-1 | | MF: | C41H70CaO9 | | MW: | 747.07 | | EINECS: | 617-954-4 | | Product Categories: | Ion Channels;antibiotic;Antibiotic Ready Made SolutionsResearch Essentials;Antibiotics;Antibiotics A to;Antibiotics G-MAntibiotics;AntibioticsAntibiotics;Chemical Structure Class;Core Bioreagents;Miscellaneous | | Mol File: | 56092-82-1.mol |
| IONOMYCIN CALCIUM SALT Chemical Properties |
| Melting point | 205-206 C | | Fp | 87 °C | | storage temp. | −20°C | | solubility | Soluble in DMSO (10mg/ml). Also soluble in ethanol or methanol | | form | White to off-white solid | | color | white to off-white | | Sensitive | Light Sensitive | | BRN | 1416163 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | NO0650000 | | HazardClass | 3 | | HS Code | 29419090 |
| IONOMYCIN CALCIUM SALT Usage And Synthesis |
| Description | Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 μM. Ionomycin (5 μM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination with phorbol 12-myristate 13-acetate (PMA; ) has commonly been used to induce the proliferation and activation of T cells, as well as to stimulate cytokine production in macrophages, in vitro. | | Chemical Properties | Powder | | Uses | Ionomycin is more effectivethan A23187 as a Ca++ionophore;
Ionomycin is used in research on Ca++ transport across biological membranes;
Ionomycin induces apoptotic degeneration of embryonic cortical neurons. | | Uses | Ionomycin calcium salt is used as a polyether antibiotic and apoptotic degeneration inducer. Ionomycin induces apoptotic degeneration of embryonic cortical neurons and cell cycle arrest at G1 phase. It is more effective than A23187 (sc-3591) and provides a useful tool for increasing intracellular Ca2+ concentration. | | General Description | Useful in cell activation experiments when calcium dose-response data are not required. Also available as a 10 mM solution in DMSO (Cat. No. 407953). | | Biological Activity | Calcium ionophore; more specific than A23187 (5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid ). | | Biochem/physiol Actions | Product does not compete with ATP. | | References | Liu et al. (1978), Ionomycin, a new polyether antibiotic; J. Antibiot., 31 815
Liu and Hermann et al. (1978), Characterization of ionomycin as a calcium ionophore; J. Biol.Chem, 253 5892 |
| IONOMYCIN CALCIUM SALT Preparation Products And Raw materials |
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