Product

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE

CAS No.：562823-84-1

Other grades of this product :

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Basic information

Product Name:	3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE
Synonyms:	3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE;3-(4-IODO-PHENYL)-1-(4''- BORANYL-PHENYL)-PROP-2-ENONE (FOR R&D ONLY);TRANS-4-IODO,4'-BORANYL-CHALCONE;MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem;MDM2 Inhibitor;Boronic acid, B-[4-[(2E)-3-(4-iodophenyl)-1-oxo-2-propen-1-yl]phenyl]-
CAS:	562823-84-1
MF:	C15H12BIO3
MW:	377.97
EINECS:
Product Categories:	Cell Cycle RegulatorsImmune Cell Signaling and Blood;Apoptosis and Cell Cycle;Cell Cycle;Immune System Regulation;Immunomodulators and Antibiotics
Mol File:	562823-84-1.mol

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Chemical Properties

storage temp.	+2C to +8C
solubility	DMSO: >30 mg/mL, soluble
form	solid

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Usage And Synthesis

General Description	A cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC₅₀ = 10 μM for MDA-MB-435, 8.8 μM for MDA-MB-231, and 7 μM for Wt-MCF7) compared to normal breast cell lines (IC₅₀ = 75 μM for MCF-10A and 63 μM for MCF-12A).
Biochem/physiol Actions	Cell permeable: yes

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Preparation Products And Raw materials

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