Product

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE

CAS No.：56715-13-0

Other grades of this product :

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Basic information

Product Name:	(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
Synonyms:	(R)-(+)-AtenololHCl;4-[(R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide;2-[4-[(2R)-2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide;2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide;2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethanamide;(R)-(+)-Atenolol,(+)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide;R(+)-ATENOLOL LESS ACTIVE ENANTIOME;Benzeneacetamide, 4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-
CAS:	56715-13-0
MF:	C14H22N2O3
MW:	266.34
EINECS:
Product Categories:	Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	56715-13-0.mol

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Chemical Properties

Melting point	148-152 °C(lit.)
Boiling point	508.0±50.0 °C(Predicted)
density	1.125±0.06 g/cm3(Predicted)
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >6.0 mg/mL
pka	13.88±0.20(Predicted)
form	solid
color	pale yellow
optical activity	[α]25/D +16°, c = 1 in 1 M HCl

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Usage And Synthesis

Description	(+)-Atenolol is an enantiomer of the β₁-adrenergic receptor (β₁-AR) antagonist (±)-atenolol . (+)-Atenolol inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (K_i = 8.61 μM). Unlike (–)-atenolol and (±)-antenolol, (+)-atenolol has no effect on blood pressure in spontaneously hypertensive rats.
Uses	Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).
Uses	Antihypertensor
Uses	less active enantiomer
Definition	ChEBI: The (R)-enantiomer of atenolol.
references	[1] stoschitzky k, egginger g, zernig g, et al. stereoselective features of (r)- and (s)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[j]. chirality, 1993, 5(1): 15-19.

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Preparation Products And Raw materials

Raw materials

Atenolol-->S(-)-ATENOLOL-->4-Hydroxyphenylacetamide-->4-Hydroxyphenylacetic acid-->Isopropylamine

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873