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| Phenobarbital sodium Basic information |
| Product Name: | Phenobarbital sodium | | Synonyms: | 5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt, 5-Ethyl-5-phenylbarbituric acid sodium salt, Luminal sodium salt, Sodium 5-ethyl-5-phenylbarbiturate;2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-, monosodium salt;5-Ethyl-5-phenylbarbituric acid sodium;Sodium ethylphenylbarbiturat;Phenobarbital Sodium Salt (contains 5% Isopropyl Alcohol at maximum);5-Ethyl-5-phenyl-2-sodiooxy-4,6(1H,5H)-pyrimidinedione;Phenobarbital sodium salt,5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt, 5-Ethyl-5-phenylbarbituric acid sodium salt, Luminal sodium salt, Sodium 5-ethyl-5-phenylbarbiturate;Phenobarbital SodiuM API | | CAS: | 57-30-7 | | MF: | C12H12N2O3.Na | | MW: | 254.22 | | EINECS: | 200-322-3 | | Product Categories: | Heterocyclic Compounds | | Mol File: | 57-30-7.mol |
| Phenobarbital sodium Chemical Properties |
| Hazard Codes | T | | Risk Statements | 25-40-43 | | Safety Statements | 22-36/37/39-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | - | | RTECS | CQ7000000 | | HazardClass | 6.1(b) | | PackingGroup | III | | Toxicity | LD50 orally in rats: 660 mg/kg (Schaffarzick, Brown) |
| Phenobarbital sodium Usage And Synthesis |
| Chemical Properties | Solution S is clear (2.2.1) and not more intensely coloured than reference solution Y7 (2.2.2, Method II). | | Uses | Phenobarbital sodium salt has been used: - to anesthetize mice for inducing ischemia-reperfusion injury
- as a positive control for the activation of constitutive androstane receptor (CAR)
- in bioluminescent yeast bioreporters (BLYAS) assay
| | Uses | Anticonvulsant; sedative-hypnotic. | | Definition | ChEBI: A barbiturate that is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups). | | Brand name | Luminal Sodium (Sterling Winthrop). | | General Description | Odorless white crystalline powder. Aqueous solutions are alkaline to litmus and phenolphthalein (pH approximately 9.3). Bitter taste. A narcotic. | | Air & Water Reactions | Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble. Aqueous solutions are unstable, but may be kept at or below 50°F for a few days. | | Reactivity Profile | Phenobarbital sodium can react with strong oxidizing agents. Incompatible with ammonium salts and chloral hydrate. Also incompatible with acids and acidic substances . | | Fire Hazard | Flash point data for Phenobarbital sodium are not available; however, Phenobarbital sodium is probably combustible. | | Biochem/physiol Actions | Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation. It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA?receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus. | | Safety Profile | Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, intravenous, intraperitoneal, intraduodenal, and subcutaneous routes. Human systemic effects by ingestion: nausea or vomiting and coma. Experimental reproductive effects. Mutation data reported. Used to treat epilepsy, as a hypnotic and sedative. When heated to decomposition it emits toxic fumes of NOx and NazO. See also BARBITURATES |
| Phenobarbital sodium Preparation Products And Raw materials |
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