Product

1-ACETYLINDOLE

CAS No.：576-15-8

Other grades of this product :

1-ACETYLINDOLE Basic information

Product Name:	1-ACETYLINDOLE
Synonyms:	N-ACETYLINDOLE;1-acetyl-1h-indol;Acetylindole;1H-Indole, 1-acetyl- (9CI);1H-Indole, 1-acetyl-;N-acetoindole;Methyl 1H-indole-1-yl ketone;1-Acetylindole,98%
CAS:	576-15-8
MF:	C10H9NO
MW:	159.18
EINECS:	209-396-1
Product Categories:	ACETYLGROUP;Indoles and derivatives;Indole;Building Blocks;Heterocyclic Building Blocks;Indoles
Mol File:	576-15-8.mol

1-ACETYLINDOLE Chemical Properties

Melting point	189 °C
Boiling point	123-125 °C/8 mmHg (lit.)
density	1.387 g/mL at 25 °C (lit.)
refractive index	n20/D 1.607(lit.)
Fp	>230 °F
storage temp.	2-8°C
CAS DataBase Reference	576-15-8(CAS DataBase Reference)
EPA Substance Registry System	1H-Indole, 1-acetyl- (576-15-8)

Safety Information

Safety Statements	24/25
WGK Germany	3
HS Code	29339990

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

1-ACETYLINDOLE Usage And Synthesis

Chemical Properties	clear yellow liquid after melting
Uses	1-Acetylindole may be used in the stereocontrolled synthesis of (±)-geissoschizine. It may be used in the preparation of (1-acetyl-κO-indolyl-κC²)tetracarbonylmanganese, via a standard cyclomanganation procedure.
Synthesis Reference(s)	Tetrahedron Letters, 29, p. 2151, 1988 DOI: 10.1016/S0040-4039(00)86696-4
General Description	Quantum chemical calculations of ground state energy, geometrical structure and vibrational wavenumbers of 1-acetylindole has been carried out using density functional (DFT/B3LYP) method. Regioselective acylations of 1-acetylindole (N-acetylindole) under Friedel-Crafts reaction has been reported. Reaction of 1-acetylindole with manganese(III) acetate in the presence of malonic acid, is reported to afford 4-acetyl-3,3a,4,8b-tetrahydro-2H-furo[3,2-b]indol-2-one.

1-ACETYLINDOLE Preparation Products And Raw materials

Preparation Products

N-ACETYLINDOLE-3-CARBOXALDEHYDE

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