1,2-PHENYLENE PHOSPHOROCHLORIDITE

CAS No.：1641-40-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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1,2-PHENYLENE PHOSPHOROCHLORIDITE Basic information

Product Name:	1,2-PHENYLENE PHOSPHOROCHLORIDITE
Synonyms:	1,3,2-Benzodioxaphosphole,2-chloro-;2-benzodioxaphosphole,2-chloro-3;O-PHENYLENE PHOSPHOROCHLORIDITE;1,2-PHENYLENE PHOSPHOROCHLORIDITE;2-CHLORO-1,3,2-BENZODIOXAPHOSPHOLE;Catechyl phosphorus chloride~2-Chloro-1,3,2-benzodioxaphosphole;1,2-Phenylene phosphorochloridite, 98+%;CATECHYL PHOSPHORUS CHLORIDE
CAS:	1641-40-3
MF:	C6H4ClO2P
MW:	174.52
EINECS:	216-690-3
Product Categories:	Phospholipids - 13C & 2H;Phosphorylating and Phosphitylating Agents;Aromatics;Heterocycles
Mol File:	1641-40-3.mol

1,2-PHENYLENE PHOSPHOROCHLORIDITE Chemical Properties

Melting point	30-35 °C(lit.)
Boiling point	80 °C20 mm Hg(lit.)
density	1.466 g/mL at 25 °C(lit.)
refractive index	n20/D 1.571(lit.)
Fp	>230 °F
storage temp.	0-6°C
form	solid
Sensitive	Moisture Sensitive
BRN	135455
Stability:	Moisture Sensitive
CAS DataBase Reference	1641-40-3(CAS DataBase Reference)
EPA Substance Registry System	1,3,2-Benzodioxaphosphole, 2-chloro- (1641-40-3)

Safety Information

Hazard Codes	C
Risk Statements	34
Safety Statements	26-36/37/39-45
RIDADR	UN 3261 8/PG 2
WGK Germany	3
F	10-21
TSCA	Yes
HazardClass	8
PackingGroup	II

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

1,2-PHENYLENE PHOSPHOROCHLORIDITE Usage And Synthesis

Chemical Properties	Colourless Liquid Which Solidifies at Low Temperature
Uses	Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs
Uses	Catalyst in synthesis of bakkane sesquiterpenes Reactant in reversible halogen-halogen ligand substitution at room temperature, and in irreversible halogen-O substitution at higher temperatures Reactant in preparation of gold(I) trimethoxybenzonitrile phosphine isolated precatalysts Reactant for preparation of pyrroles by TMSOTf-catalyzed Arbuzov reaction Phosphorylation agent Reactant for reparation of vinyl-substituted spirophosphoranes and vinylphosphonates via Markovnikov addition

1,2-PHENYLENE PHOSPHOROCHLORIDITE Preparation Products And Raw materials

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