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| BAX INHIBITING PEPTIDE V5 (BIP-V5) Basic information |
| Product Name: | BAX INHIBITING PEPTIDE V5 (BIP-V5) | | Synonyms: | BAX INHIBITOR PEPTIDE V5, >99%;Bax inhibitor peptide V5,Val-Pro-Met-Leu-Lys, BIP-V5,BAX Inhibiting Peptide V5, >99%;Val-Pro-Met-Leu-Lys;VAL-PRO-MET-LEU-LYS;BIP-V5;BAX INHIBITING PEPTIDE V5 (BIP-V5);Bax inhibitor peptide V5 (BIP-V5);VAL-PRO-MET-LEU-LYS;BIP-V5;BAX INHIBITING PEPTIDE V5;L-Lysine, L-valyl-L-prolyl-L-methionyl-L-leucyl- | | CAS: | 579492-81-2 | | MF: | C27H50N6O6S | | MW: | 586.79 | | EINECS: | | Product Categories: | | Mol File: | 579492-81-2.mol |
| BAX INHIBITING PEPTIDE V5 (BIP-V5) Chemical Properties |
| Boiling point | 907.2±65.0 °C(Predicted) | | density | 1.185±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | ≥29.35 mg/mL in DMSO; insoluble in EtOH; ≥91.4 mg/mL in H2O | | form | lyophilized powder | | pka | 3.31±0.10(Predicted) |
| BAX INHIBITING PEPTIDE V5 (BIP-V5) Usage And Synthesis |
| Description | Bax inhibitor peptide V5 is an inhibitor of Bax. It decreases levels of the pro-apoptotic proteins Bax, Bad, and NF-ĸB p65 and increases levels of the anti-apoptotic proteins X-linked inhibitor of apoptosis (XIAP) and Bcl-2 in isolated mouse pancreatic islets when used at a concentration of 100 μM. It inhibits apoptosis induced by etoposide in Hep3B human hepatoma cells when used at a concentration of 200 μM. Bax inhibitor peptide V5 (5 mg/ml, i.c.v.) decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test, indicating an improvement in sensorimotor function, in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation. Bax inhibitor peptide V5, when used at a concentration of 100 μM in syngeneic pancreatic islet cells prior to transplantation, inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in a mouse model of diabetes induced by streptozotocin (STZ; ). | | Biochem/physiol Actions | BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet and anti-cancer drug. | | references | [1]. sawada m, hayes p, matsuyama s. cytoprotective membrane-permeable peptides designed from the bax-binding domain of ku70. nat cell biol, 2003, 5(4): 352-357.[2]. rivas-carrillo jd, soto-gutierrez a, navarro-alvarez n, et al. cell-permeable pentapeptide v5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. diabetes, 2007, 56(5): 1259-1267. |
| BAX INHIBITING PEPTIDE V5 (BIP-V5) Preparation Products And Raw materials |
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