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| 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Basic information |
| 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Chemical Properties |
| Melting point | 148-152 °C(Solv: dichloromethane (75-09-2)) | | Boiling point | 462.0±34.0 °C(Predicted) | | density | 1.037±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | DMSO: >7mg/mL | | form | solid | | pka | 4.23±0.10(Predicted) |
| 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Usage And Synthesis |
| Uses | AC 55649 is a potent and selective RARβ2 receptor agonist (1). RARβ2 receptor agonists are potential drug candidates for developing treatment for type 2 diabetes and hepatic steatosis (2). | | Biological Activity | Potent, isoform-selective RAR β 2 receptor agonist (pEC 50 values are 6.9, 5.7 and 5.6 at RAR β 2, RAR β 1 and RAR α respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7. | | Biochem/physiol Actions | AC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580. |
| 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials |
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