Other grades of this product :
| I-PROPYLISOCYANIDE Basic information |
| I-PROPYLISOCYANIDE Chemical Properties |
| Boiling point | 75 °C(lit.) | | density | 0.733 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.371(lit.) | | Fp | 69 °F | | storage temp. | 2-8°C | | form | liquid | | Specific Gravity | 0.7596 | | color | colorless | | Stability: | store cold |
| I-PROPYLISOCYANIDE Usage And Synthesis |
| Uses | Isopropyl isocyanide may be used in the preparation of:- Ugi ligand A2C11I1, which is employed in the solid-phase Ugi synthesis.
- Pentafluorophenyl (PFP) functional monomers, via Passerini reaction.
- Dinuclear copper complex [Cu2(μ-PiPr2bipy)2{μ-CNCH(CH3)2}](PF6)2 [PiPr2bipy = 6-(diisopropylphosphanyl)-2,2′-bipyridine].
- (3E)-(Imino)thiaisoindoline 1,1-dioxide derivative.
- N,N′-diisopropylcarbodiimide (DIC) analog via reaction with propan-2-amine.
- 1-t-butyl-2-isopropyldiaziridinone via reaction with 2-methyl-2-nitrosopropane
- isopropyl isocyanate via reaction with ozone
- 1-phthalimidoazetidines via [1+3]cycloaddition reaction with 1-pththalimidoaziridines
| | Preparation | To a flask containing 100 ml (0.85 mole) of distilled quinoline is added with stirring 41 gm (0.214 mole) of /7-toluenesulfonyl chloride (see Note), and the solution is warmed to 75°C. Then 18.4 gm (0.212 mole) of isopropylformamide is added and the pressure of the system is reduced to 70 mm Hg. The isopropylisonitrile as it forms distills into a liquid nitrogencooled receiver. (Dry ice is not as effective but may be used.) The product is redistilled to afford 4.2 gm (30%), b.p. 88-89°C (735 mm Hg).
| | General Description | Isopropyl isocyanide is an alkyl isocyanide. |
| I-PROPYLISOCYANIDE Preparation Products And Raw materials |
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