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| ACETYLTHIOCHOLINE CHLORIDE Basic information |
| Product Name: | ACETYLTHIOCHOLINE CHLORIDE | | Synonyms: | (2-acetylthio)-n,n,n-trimethylethanaminumchloride;ammonium,(2-mercaptoethyl)trimethyl-,chloride,acetate;N-(2-MERCAPTOETHYL)TRIMETHYLAMMONIUM CHLORIDE ACETATE;S-ACETYLTHIOCHOLINE CHLORIDE;THIOCHOLINE CHLORIDE ACETATE;ACETYLTHIOCHOLINE CHLORIDE;N-[2-(Acetylthio)ethyl]trimethylaminium·chloride;2-acetylsulfanylethyl(trimethyl)azanium chloride | | CAS: | 6050-81-3 | | MF: | C7H16ClNOS | | MW: | 197.72 | | EINECS: | 227-953-7 | | Product Categories: | Agonists;Cholinergics;Neurotransmitters | | Mol File: | 6050-81-3.mol |
| ACETYLTHIOCHOLINE CHLORIDE Chemical Properties |
| Melting point | 199-201°C | | storage temp. | -20°C | | solubility | DMSO (Slightly), Water (Slightly, Heated, Sonicated) | | form | powder | | color | White to Off-White | | CAS DataBase Reference | 6050-81-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-41 | | Safety Statements | 26-36-39 | | WGK Germany | 3 | | RTECS | BR6954000 | | HS Code | 29309070 |
| ACETYLTHIOCHOLINE CHLORIDE Usage And Synthesis |
| Chemical Properties | white powder | | Uses | Acetylthiocholine chloride has been used to determine the acetylcholine esterase activity of semen exosomes (SE). It has also been used as a substrate for acetylcholine esterase in microcalorimetric study of its kinetic parameters. | | Biochem/physiol Actions | Acetylcholinesterase (AChE) enzyme plays an important physiological role in the neurotransmission process. | | Purification Methods | The chloride can be purified in the same way as the bromide, and it can be prepared from the iodide. A few milligrams dissolved in H2O can be purified by applying onto a Dowex-1 Cl-resin column (prepared by washing with N HCl followed by CO3 -free H2O until the pH is 5.8). After equilibration for 10minutes, elution is started with CO3 -free distilled H2O, and 3mL fractions are collected and their OD values at 229nm are measured. The fractions with appreciable absorption are pooled and lyophilised at 0-5o. Note that at higher temperatures decomposition of the ester is appreciable; hydrolysis is appreciable at pH >10.5/20o. The residue is dried in vacuo over P2O5, checked for traces of iodine (add conc H2SO4 and heat, violet vapours are released), and recrystallise it from propan-1-ol. [Gal & Roth Clin Chim Acta 2 316 1957, Beilstein 4 IV 1585.] |
| ACETYLTHIOCHOLINE CHLORIDE Preparation Products And Raw materials |
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