TETRAETHYL METHYLENEDIPHOSPHONATE

CAS No.：1660-94-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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TETRAETHYL METHYLENEDIPHOSPHONATE Basic information

Product Name:	TETRAETHYL METHYLENEDIPHOSPHONATE
Synonyms:	methylenedi-phosphonicacitetraethylester;METHYLENEDIPHOSPHONIC ACID TETRAETHYL ESTER;AURORA KA-1506;BIS(DIETHOXYPHOSPHINYL)METHANE;TETRAETHYL(METHYLENE)BISPHOSPHONATE;TETRAETHYL METHYLENEDIPHOSPHONATE;Tetraethyl methylenediphosphonate, 98+%;methanediyl-bis-phosphonic acid tetraethyl ester
CAS:	1660-94-2
MF:	C9H22O6P2
MW:	288.21
EINECS:	216-764-5
Product Categories:	Naphthyridine,Quinoline
Mol File:	1660-94-2.mol

TETRAETHYL METHYLENEDIPHOSPHONATE Chemical Properties

Boiling point	171-174 °C11 mm Hg(lit.)
density	1.16 g/mL at 25 °C(lit.)
refractive index	n20/D 1.442(lit.)
Fp	>230 °F
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
Specific Gravity	1.160
color	Clear yellow to yellow-brown
Water Solubility	Slightly miscible with water.
BRN	1813241
InChIKey	STJWVOQLJPNAQL-UHFFFAOYSA-N
CAS DataBase Reference	1660-94-2(CAS DataBase Reference)
EPA Substance Registry System	Phosphonic acid, methylenebis-, tetraethyl ester (1660-94-2)

Safety Information

Hazard Codes	Xi,C
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	SZ9150000
Hazard Note	Corrosive
TSCA	Yes
HS Code	29319090

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

TETRAETHYL METHYLENEDIPHOSPHONATE Usage And Synthesis

Chemical Properties	clear yellow to yellow-brown liquid
Uses	Tetraethyl methylidenebisphosphonate, can be used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters as potent anti-inflammatory agents. It is also an intermediate for the synthesis of new bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity.
Uses	Reactant for synthesis of: Dual substrate-site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase Unnatural alpha-amino acid derivatives containing gem-biphosphonates Biphenyl sulfonylamino Me bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption Lycopene via Wittig-Horner reaction Alkylaminoethylbisphosphinic acids to target farnesyl diphosphate synthase Aromatic bisphosphonates for use as inhibitors of geranylgeranyl diphosphate synthase Precursor for synthesis of dendritic polyglycerol anions used toward L-selectin inhibition
Synthesis Reference(s)	Synthetic Communications, 20, p. 1865, 1990 DOI: 10.1080/00397919008053112Tetrahedron Letters, 34, p. 1515, 1993 DOI: 10.1016/S0040-4039(00)60333-7

TETRAETHYL METHYLENEDIPHOSPHONATE Preparation Products And Raw materials

Preparation Products

DIETHYL VINYLPHOSPHONATE-->METHYLENEBIS(PHOSPHONIC DICHLORIDE)-->DIETHYL IODOMETHYLPHOSPHONATE

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