trans-Chalcone

trans-Chalcone
  • CAS No.:614-47-1

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  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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trans-Chalcone Basic information
Product Name:trans-Chalcone
Synonyms:PHENYL STYRYL KETONE;(2E)-1,3-DIPHENYLPROP-2-EN-1-ONE;2-BENZALACETOPHENONE;2-BENZYLIDENEACETOPHENONE;3-PHENYLACRYLOPHENONE;TRANS-BENZYLIDENEACETOPHENONE;TRANS-CHALCONE;1,3-DIPHENYL-2-PROPEN-1-ONE
CAS:614-47-1
MF:C15H12O
MW:208.26
EINECS:210-383-8
Product Categories:
Mol File:614-47-1.mol
trans-Chalcone Chemical Properties
Melting point 55-59 °C
Boiling point 208 °C25 mm Hg(lit.)
density 1.0712
refractive index 1.5361 (estimate)
Fp >230 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly)
form Solid
color Pale Yellow
Water Solubility Soluble in chloroform, ether, benzene, and ethanol (slightly). Insoluble in water.
Merck 14,2037
BRN 509985
CAS DataBase Reference614-47-1(CAS DataBase Reference)
NIST Chemistry ReferenceBenzalacetophenone(614-47-1)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37
Safety Statements 22-36/37/39-45
WGK Germany 3
RTECS UD5576750
HS Code 29143990
MSDS Information
ProviderLanguage
1,3-Diphenyl-2-propen-1-one English
ACROS English
SigmaAldrich English
ALFA English
trans-Chalcone Usage And Synthesis
Descriptiontrans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.
Usestrans-Chalcone is a positive allosteric modulator of α7 nicotinic acetylcholine receptors and exhibits antioxidant activity.
Applicationtrans-Chalcone was used in the synthesis of cis and trans diphenyl cyclopropane. It was also used in screening of surface adsorbed species of isobutybenzene and 4-isobutylacetophenone on bulk fosfotungstic Wells-Dawson acid (H6P2W18O62.xH2O).
Preparationtrans-Chalcones have been obtained in good yields and selectivities following an environmentally friendly methodology by using montmorillonite KSF as a reusable heterogeneous catalyst.Clay-catalysed solventless synthesis of trans-chalcones
Synthesis Reference(s)Journal of the American Chemical Society, 104, p. 4724, 1982 DOI: 10.1021/ja00381a058
General Descriptiontrans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.
Biological Activitytrans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.
Biochem/physiol Actionstrans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.

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