2-Chloro-4-methylaniline

CAS No.：615-65-6

Other grades of this product :

2-Chloro-4-methylaniline Basic information

Description

Product Name:	2-Chloro-4-methylaniline
Synonyms:	3-CHLORO-4-AMINOTOLUENE;4-AMINO-3-CHLOROTOLUENE;2-CHLORO-P-TOLUIDINE;2-CHLORO-4-METHYLANILINE;2-CHLORO-4-TOLUIDINE;1-AMINO-2-CHLORO-4-METHYLBENZENE;2-Chlor-4-toluidin;2-chlor-4-toluidin(czech)
CAS:	615-65-6
MF:	C7H8ClN
MW:	141.6
EINECS:	210-440-7
Product Categories:	API Intermediate;Anilines, Aromatic Amines and Nitro Compounds;Intermediates of Dyes and Pigments
Mol File:	615-65-6.mol

2-Chloro-4-methylaniline Chemical Properties

Melting point	7 °C (lit.)
Boiling point	223-225 °C (lit.)
density	1.151 g/mL at 25 °C (lit.)
refractive index	n20/D 1.575(lit.)
Fp	211 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	methanol: soluble
form	Liquid
pka	3.09±0.10(Predicted)
color	Clear yellow to pale brown
BRN	774514
CAS DataBase Reference	615-65-6(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 2-chloro-4-methyl-(615-65-6)
EPA Substance Registry System	Benzenamine, 2-chloro-4-methyl- (615-65-6)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38-22-33
Safety Statements	36/37-37/39-26-45-36/37/39
RIDADR	UN 3429 6.1/PG 3
WGK Germany	3
RTECS	XU5110000
F	8-9-23
Hazard Note	Harmful
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29214200
Hazardous Substances Data	615-65-6(Hazardous Substances Data)

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

2-Chloro-4-methylaniline Usage And Synthesis

Description	2-Chloro-4-methylaniline was used in determination of aniline derivatives in environmental water samples using on-line combination of supported liquid membrane extraction and liquid chromatography. It was also used in determination of amines in environmental water samples by gas chromatography–mass spectrometry. It is an intermediate used to prepare reverse transcriptase inhibitors of HIV-1.
Chemical Properties	clear yellow to pale brown liquid
Chemical Properties	The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.
Uses	2-Chloro-4-methylaniline is an intermediate used to prepare reverse transcriptase inhibitors of HIV-1.
Uses	2-Chloro-4-methylaniline was used in determination of aniline derivatives in environmental water samples using on-line combination of supported liquid membrane extraction and liquid chromatography. It was also used in determination of amines in environmental water samples by gas chromatography–mass spectrometry.
Safety Profile	Poison by ingestion. A severe eye and skin irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland NOx. See also other chloro toluidine entries.
Potential Exposure	Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.
Shipping	UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials
Incompatibilities	Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.

2-Chloro-4-methylaniline Preparation Products And Raw materials

Preparation Products

2-CHLORO-4-METHYLPHENYL ISOTHIOCYANATE-->3,4-Dichlorotoluene-->4-BROMO-3-CHLOROTOLUENE

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