Other grades of this product :
| W-7 HYDROCHLORIDE Basic information |
| W-7 HYDROCHLORIDE Chemical Properties |
| Melting point | 220-222 °C | | storage temp. | -20°C | | solubility | methanol: 25 mg/mL, clear, colorless | | form | Off-white crystalline solid | | color | White to Off-White | | BRN | 6030174 | | CAS DataBase Reference | 61714-27-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | QK0786000 | | F | 3-10 | | HS Code | 2935909099 |
| W-7 HYDROCHLORIDE Usage And Synthesis |
| Description | Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-7 is a cell-permeable antagonist of calmodulin (Ki = 11 μM). Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (Ki = 70 and 300 μM, respectively). | | Chemical Properties | White Crystalline Solid | | Uses | W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities. | | Uses | N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride has been used to study its effect of on coated pit staining. | | General Description | A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM). | | Biological Activity | Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M). | | Biochem/physiol Actions | Cell permeable: yes |
| W-7 HYDROCHLORIDE Preparation Products And Raw materials |
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