Product

4-HYDROXY MEPHENYTOIN

CAS No.：61837-65-8

Other grades of this product :

4-HYDROXY MEPHENYTOIN Basic information

Product Name:	4-HYDROXY MEPHENYTOIN
Synonyms:	(+/-) -HYDROXYMEPHENYTOIN;5-Ethyl-5-(4-hydroxyphenyl)-3-Methyl-;(±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione;4-Hydroxy-5-ethyl-3-methyl-5-phenylimidazolidin-2-one;4'-Hydroxymephenitoyn;5-(p-Hydroxyphenyl)-3-methyl-5-ethyl-imidazolidine-2,4-dione;5-Ethyl-3-methyl-5-(4-hydroxyphenyl)hydantoin;5-Ethyl-3-methyl-5-(4-hydroxyphenyl)imidazolidine-2,4-dione
CAS:	61837-65-8
MF:	C12H14N2O3
MW:	234.25
EINECS:
Product Categories:	Chemical Synthesis;Heterocyclic Building Blocks;Metabolites;Heterocycles;Building Blocks;Imidazolines/Imidazolidines;Hydantoins & Derivatives;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:	61837-65-8.mol

4-HYDROXY MEPHENYTOIN Chemical Properties

Melting point	153-154 °C
density	1.249±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >5mg/mL
pka	8.31±0.70(Predicted)
form	Solid
color	white

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

4-HYDROXY MEPHENYTOIN Usage And Synthesis

Chemical Properties	White Solid
Uses	CYP2C19 metabolite of Mephenytoin
Uses	Pharmacological activity investigating:• ;The drug effects on metabolization1• ;In vitro cytochrome P450 activity in microsomes2Analyte for electron-capture gas chromatography procedures3
Uses	Pharmacological activity investigating: The drug effects on metabolization In vitro cytochrome P450 activity in microsomes Analyte for electron-capture gas chromatography procedures
General Description	CYP2C19 metabolite of mephenytoin.
Biochem/physiol Actions	4-Hydroxymephenytoin catabolism displays genetic polymorphism and is a direct indicator of Cytochrome P450 2C19 (CYP2C19) activity. Detection and quantification of 4-hydroxymephenytoin in biological samples by HPLC method is well optimized.

4-HYDROXY MEPHENYTOIN Preparation Products And Raw materials

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