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| 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Basic information |
| Product Name: | 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE | | Synonyms: | 4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL;4α-pma;4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%;(1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate;4α-TPA;4-alpha-Phorbol 12-Myristate 13-Acetate >99%;4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate;4-alpha-PMA, 4-alpha-TPA | | CAS: | 63597-44-4 | | MF: | C36H56O8 | | MW: | 616.83 | | EINECS: | | Product Categories: | metabolite | | Mol File: | 63597-44-4.mol |
| 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media. | | form | solid | | color | white | | Sensitive | Light Sensitive |
| 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Usage And Synthesis |
| Uses | 4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes. | | Biochem/physiol Actions | Negative control for phorbol ester activation of protein kinase C. |
| 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Preparation Products And Raw materials |
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