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| Paroxetine maleate Basic information |
| Product Name: | Paroxetine maleate | | Synonyms: | BRL-29060;FG-7051;(3S-TRANS)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE MALEATE;(3S,4R)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)-PIPERIDINE MALEATE;(-)-alpha-4-(4-fluorophenyl)-3-(1,3-benzdioxolyl-(3))-oxymethylpiperidinema;,(z)-2-butenedioate;3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-3-((trans-(-)-piperidin;PAROXETINE MALEATE | | CAS: | 64006-44-6 | | MF: | C23H24FNO7 | | MW: | 445.44 | | EINECS: | 636-343-3 | | Product Categories: | | Mol File: | 64006-44-6.mol |
| Paroxetine maleate Chemical Properties |
| Melting point | 136-138°C | | alpha | D -87° (c = 5 in ethanol) | | Fp | 9℃ | | storage temp. | 2-8°C | | solubility | DMSO: ~12 mg/mL | | form | solid | | color | white |
| Paroxetine maleate Usage And Synthesis |
| Uses | Paroxetine maleate is a selective serotonin uptake inhibitor. | | Definition | ChEBI: A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibi
ion of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 | | General Description | Paroxetine, marketed under trade names such as Paxil? or Aropax, is an SSRI antidepressant used to treat many conditions in adults from major depression and obsessive-compulsive disorder to several anxiety disorders. Suitable uses for this certified solution standard include as a starting material for calibrators and controls in LC/MS or GC/MS paroxetine testing applications such as urine drug testing, prescription monitoring, clinical toxicology, or forensic analysis. | | Biological Activity | Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K i = 0.05 nM). K i values are 1.1, 350 and 1100 nM for inhibition of [ 3 H]-5-HT, [ 3 H]-l-NA and [ 3 H]-DA uptake respectively. Displays minimal affinity for a 1 -, a 2 - or b-adrenoceptors, 5-HT 2A , 5-HT 1A , D 2 or H 1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (K i = 42 nM). Antidepressant and anxiolytic in vivo . | | Biochem/physiol Actions | Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache. |
| Paroxetine maleate Preparation Products And Raw materials |
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