5-(TRIFLUOROMETHOXY)ISATIN

CAS No.：169037-23-4

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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5-(TRIFLUOROMETHOXY)ISATIN Basic information

Product Name:	5-(TRIFLUOROMETHOXY)ISATIN
Synonyms:	5-(Trifluoromethoxy)isatin 97%;5-(trifluoroMethoxy)-2,3-dihydro-1H-indole-2,3-dione;5-(Trifluoromethoxy)indole-2,3-dione;5-(Trifluoromethoxy)-1H-indole-2,3-dione, 5-(Trifluoromethoxy)indoline-2,3-dione, 2,3-Dihydro-2,3-dioxo-5-(trifluoromethoxy)-1H-indole;5-(TRIFLUOROMETHOXY)ISATIN;5-(TRIFLUOROMETHOXYL)INDOLINE-2,3-DIONE;BUTTPARK 34\07-90;5-(Trifluoromethoxy)indoline-2,3-dione
CAS:	169037-23-4
MF:	C9H4F3NO3
MW:	231.13
EINECS:	1592732-453-0
Product Categories:	Fused Ring Systems;Building Blocks;blocks;IndolesOxindoles;Heterocyclic Building Blocks;Indoles;Indane/Indanone and Derivatives
Mol File:	169037-23-4.mol

5-(TRIFLUOROMETHOXY)ISATIN Chemical Properties

Melting point	170-172 °C(lit.)
density	1.562±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	8.49±0.20(Predicted)
form	powder to crystal
color	Light yellow to Brown
Water Solubility	Insoluble in water.
CAS DataBase Reference	169037-23-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Safety Statements	24/25
WGK Germany	3
Hazard Note	Irritant/Keep Cold
HS Code	29339900

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

5-(TRIFLUOROMETHOXY)ISATIN Usage And Synthesis

Uses

5-(Trifluoromethoxy)isatin is used as a reactant for preparation of oxindole derivatives as TAk1 kinase inhibitors and of isatin thiosemicarbazones via condensation with thiosemicarbazones as herpes simplex virus (HSV) inhibitors. It is also used as a reactant for synthesis of 3-substituted 2-indolinone RET kinase inhibitors and for preparation of indolone acetamides as antiseizure agents.

5-(TRIFLUOROMETHOXY)ISATIN Preparation Products And Raw materials

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