MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE

CAS No.：65144-34-5

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE Basic information

Product Name:	MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE
Synonyms:	N-(METHOXYSUCCINYL)-L-ALANYL-L-ALANYL-L-PROLYL-L-VALINE CHLOROMETHYLKETONE;methoxysuccinyl-alanyl-alanyl-prolyl-valinechloromethylketone;N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL CHLOROMETHYL KETONE;MEOSUC-APPV-CMK;MEOSUC-AAPV-CMK;MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE;MEOSUC-ALA-ALA-PRO-VAL-CMK;ELASTASE INHIBITOR III
CAS:	65144-34-5
MF:	C22H35ClN4O7
MW:	502.99
EINECS:
Product Categories:	ProteaseInhibitors
Mol File:	65144-34-5.mol

MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE Chemical Properties

Melting point	159-161 °C
Boiling point	809.4±65.0 °C(Predicted)
density	1.234±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	ethanol: 50 mg/mL, clear, colorless
pka	13.05±0.20(Predicted)
form	Solid
Sensitive	Moisture Sensitive
BRN	6167019

Safety Information

Safety Statements	22-24/25
WGK Germany	3
F	10

MSDS Information

Provider	Language
SigmaAldrich	English

MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE Usage And Synthesis

Uses	A potent irreversible inhibitor of human leukocyte elastase
Definition	ChEBI: A tripeptide derived from methoxysuccinyl-Ala-Ala-Pro-Val by conversion of the terminal carboxy group to the corresponding chloromethyl ketone.
General Description	N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is a tetrapeptide, cell-permeable and non-cytotoxic inhibitor.
Biochem/physiol Actions	N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone acts as a competitive inhibitor of human leukocyte elastase (HLE).

MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE Preparation Products And Raw materials

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