AC-DEVD-CHO

CAS No.：169332-60-9

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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AC-DEVD-CHO Basic information

Product Name:	AC-DEVD-CHO
Synonyms:	Ac-DEVD-CHO,N-Acetyl-Asp-Glu-Val-Asp-al, >98%;AC-DEVD-CHO?, >98%;Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem;N-ACETYL-L-ALPHA-ASPARTYL-L-ALPHA-GLUTAMYL-N-(2-CARBOXY-1-FORMYLETHYL)-L VALINAMIDE;N-AC-ASP-GLU-VAL-ASP-CHO;N-ACETYL-ASP-GLU-VAL-ASP-AL;N-ACETYL-ASP-GLU-VAL-ASP-CHO (ALDEHYDE);CPP32/APOPAIN INHIBITOR
CAS:	169332-60-9
MF:	C20H30N4O11
MW:	502.47
EINECS:
Product Categories:	peptides;Caspase 10;Caspase 3;Caspase 7;Caspase 8;Caspase Inhibitors;Caspase Inhibitors and Substrates;Peptides and Proteins;Peptides for Cell Biology;Protease Inhibitor Specificity Index;Protease Inhibitors;A to C;A-AM;Aldehydes;and Substrates;Apoptosis and Cell Cycle;Apoptosis Enzymes;Application Index;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Carbonyl Compounds;Caspases;Cell Biology;Cell Signaling and Neuroscience;Cell Signaling Enzymes;Chemical Synthesis;Enzyme Inhibitors;Enzyme Inhibitors by Enzyme;Enzymes;Inhibitors;Organic Building Blocks;Pepetides
Mol File:	169332-60-9.mol

AC-DEVD-CHO Chemical Properties

Boiling point	1021.1±65.0 °C(Predicted)
density	1.374±0.06 g/cm3(Predicted)
RTECS	EK7643000
storage temp.	-20°C
solubility	H₂O: 1 mg/mL
form	powder
pka	4.19±0.10(Predicted)
color	white
Sensitive	Moisture Sensitive

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

AC-DEVD-CHO Usage And Synthesis

Uses	Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase
Uses	N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.
Definition	ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde. It is an inhibitor of caspase-3/7.
General Description	N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.
Biochem/physiol Actions	N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.

AC-DEVD-CHO Preparation Products And Raw materials

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