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| (-)-8-PHENYLMENTHOL Basic information |
| Product Name: | (-)-8-PHENYLMENTHOL | | Synonyms: | (-)-PHENMENTHOL;(-)-8-PHENYLMENTHOL;Cyclohexanol, 5-methyl-2-(1-methyl-1-phenylethyl)-, (1R,2S,5R)-;(-)-8-Phenylmenthol, GC 97%;5-METHYL-2-(1-METHYL-1-PHENYLETHYL)-(1R,2S,5R)-CYCLOHEXANOL;(-)-8-Phenylmenthol,98%;(-)-8-Phenylmenthol,97%;(1R,2S,5R)-5-Methyl-2-(2-phenylpropan-2-yl)cyclohexanol | | CAS: | 65253-04-5 | | MF: | C16H24O | | MW: | 232.36 | | EINECS: | | Product Categories: | | Mol File: | 65253-04-5.mol |
| (-)-8-PHENYLMENTHOL Chemical Properties |
| Boiling point | 130 °C (0.7501 mmHg) | | alpha | -26°(20/D, c=2, C2H5OH) | | density | 0.999 g/mL at 20 °C (lit.) | | refractive index | n20/D 1.53(lit.) | | Fp | >230 °F | | storage temp. | Sealed in dry,2-8°C | | solubility | Chloroform (Slightly), Methanol (Very Slightly) | | pka | 15.21±0.60(Predicted) | | form | Viscous Liquid | | color | Clear colorless to light yellow | | Specific Gravity | 0.999 | | optical activity | [α]20/D 26°, c = 2 in ethanol | | λmax | 259nm(CH2Cl2)(lit.) | | BRN | 3651167 | | CAS DataBase Reference | 65253-04-5(CAS DataBase Reference) |
| (-)-8-PHENYLMENTHOL Usage And Synthesis |
| Chemical Properties | CLEAR COLOURLESS OILY LIQUID | | Uses | (-)-8-Phenylmenthol is used to prepare piperidine-based analogs of cocaine as monoamine reuptake inhibitors. It is also used to prepare quinuclidinyl (fluoroalkyl)benzilate as muscarinic receptor antagonist. | | Purification Methods | Dissolve the menthol in toluene, dry (Na2SO4), evaporate and chromatograph it on a silica gel column and eluting with 5% Et2O in pet ether to give an oil with the desired rotation. IR has max 3420cm-1 (OH) with consistent 1H NMR [Corey & Ensley J Org Chem 43 1610 1978, Whitesell et al. Tetrahedron 42 2993 1986, Bednarski & Danishefsky J Am Chem Soc 108 7060 1986]. |
| (-)-8-PHENYLMENTHOL Preparation Products And Raw materials |
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