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| (-)-BICUCULLINE METHBROMIDE Basic information |
| Product Name: | (-)-BICUCULLINE METHBROMIDE | | Synonyms: | (6R)-6-[(5S)-6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one;(-)-BICUCULLINE METHBROMIDE;[r-(r*,s*)]-5-(6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquindinium bromide;1(s),9(r)-(-)-bicuculline methobromide;(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1);1(S),9(R)-(-)-Bicuculline methbromide | | CAS: | 66016-70-4 | | MF: | C21H20NO6.Br | | MW: | 462.294 | | EINECS: | | Product Categories: | | Mol File: | 66016-70-4.mol |
| (-)-BICUCULLINE METHBROMIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | aqueous base: unstable | | form | solid | | color | white |
| (-)-BICUCULLINE METHBROMIDE Usage And Synthesis |
| Uses | 1(S),9(R)-(-)-Bicuculline methbromide has been used:- as a γ-aminobutyric acid (GABAA) receptor A antagonist: in cortical neuron culture
- in artificial cerebrospinal fluid (ACSF) formature dentate granule neurons
- in hypothalamic explant cultures
| | Biochem/physiol Actions | 1(S),9(R)-(?)-Bicuculline methbromide is a GABAA receptor antagonist, which blocks Ca2+-activated potassium (SK) channels. It is the water-soluble derivative of (+)-bicuculline. |
| (-)-BICUCULLINE METHBROMIDE Preparation Products And Raw materials |
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