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| 2-Acetylphenothiazine Basic information |
| 2-Acetylphenothiazine Chemical Properties |
| Melting point | 180-185 °C (lit.) | | Boiling point | 455.7±34.0 °C(Predicted) | | density | 1.249±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | pka | -2.45±0.20(Predicted) | | form | Dark yellow-orange powder | | color | Yellow to Dark Orange | | λmax | 244nm(MeOH)(lit.) | | CAS DataBase Reference | 6631-94-3(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22-52/53 | | Safety Statements | 60-61 | | WGK Germany | 3 | | HS Code | 2934309090 |
| 2-Acetylphenothiazine Usage And Synthesis |
| Description | 2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 μM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 μM. | | Chemical Properties | Yellow white or green crystalline powder | | Uses | 2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells. | | Uses | 2-Acetylphenothiazine was used as a NADPH oxidase (NOX) inhibitor in human platelet functional responses and intracellular signaling pathways. It was also used in the synthesis of 2-phenothiazin-2′-yl-cinchoninic acid derivatives. |
| 2-Acetylphenothiazine Preparation Products And Raw materials |
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