Other grades of this product :
| CP-944629 Basic information |
| Product Name: | CP-944629 | | Synonyms: | CP-944629;1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-6-[4-(2,4,5-trifluorophenyl)-5-oxazolyl]-;CP-944629 >=98% (HPLC) | | CAS: | 668990-94-1 | | MF: | C19H15F3N4O | | MW: | 372.34 | | EINECS: | | Product Categories: | | Mol File: | 668990-94-1.mol |
| CP-944629 Chemical Properties |
| density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | room temp | | form | powder | | pka | 2.70±0.50(Predicted) | | color | white to beige |
| CP-944629 Usage And Synthesis |
| Biochem/physiol Actions | CP-9446219 is a potent p38alpha (p38α) inhibitor (IC50 = 1.8 nM) with no inhibitory potency against a panel of 26 other knases (IC50 >10 μM), including p38gamma (p38γ) and p38delta (p38δ), MKK1, MAPK2/ERK2, JNK, MAPKAP-K1a, and MAPKAP-K2. CP-944629 effectively inhibits LPS-stimulated cellular TNF-α production in vitro (IC50 = 63 and 8.3 nM, using human whole blood and isolated mononuclear cells, respectively) and in rats in vivo (ED50 = 0.1 mg/kg p.o.) with good pharmacokinetic profile and oral availability (F = 66%/monkey, 54%/rat). |
| CP-944629 Preparation Products And Raw materials |
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