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| 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Basic information |
| Product Name: | 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID | | Synonyms: | 3,3’,5,5’-tetraiodo-thyroaceticaci;3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)-benzeneaceticaci;3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneaceticacid;acide3,5,3’,5’-tetraiodothyroacetique;Levothyroxine – Impurity D;Liothyronine EP Impurity D;tetraiodothyroaceticacid;4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid | | CAS: | 67-30-1 | | MF: | C14H8I4O4 | | MW: | 747.83 | | EINECS: | 200-649-1 | | Product Categories: | Aromatic Phenylacetic Acids and Derivatives;Aromatics;Drug Analogues;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 67-30-1.mol |
| 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Chemical Properties |
| Melting point | 219-220 °C (decomp) | | Boiling point | 544.8±50.0 °C(Predicted) | | density | 2.727±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | solubility | acetone: soluble19.60 - 20.40mg/mL, clear, colorless (or faintly yellow to yellow) | | form | powder to crystal | | pka | 3.98±0.10(Predicted) | | color | White to Yellow to Green | | InChIKey | PPJYSSNKSXAVDB-UHFFFAOYSA-N |
| Hazard Codes | T+ | | Risk Statements | 28 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1/PG 1 | | WGK Germany | 3 | | RTECS | CY1585800 |
| 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Usage And Synthesis |
| Uses | Thyroid hormone analogue | | Uses | 3,3′,5,5′-Tetraiodothyroacetic acid has been used: - as a positive control to study the effects of ioxynil (IOX)
- diethylstilbestrol (DES) exposure on zebrafish embryos
- to study its effects on long-term potentiation (LTP) and long-term depression (LTD) in the dentate gyrus in urethane-anesthetized male rats
- to determine its influence on the actions of thyroid-stimulating hormone
- thyroid-stimulating immunoglobulins in orbital fibroblast
| | Definition | ChEBI: A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'. | | Biochem/physiol Actions | Studies in rats have reported that Tetrac may regulate TSH secretion under in vivo conditions1. |
| 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Preparation Products And Raw materials |
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