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| 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Basic information |
| Product Name: | 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE | | Synonyms: | GBR 12935 dihydrochloride, >=98%;GBR 12935 (hydrochloride);GBR 12935 DIHYDROCHLORIDE;1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE;GBR-12935 2HCL;GBR 12935 HCl;1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride;Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2) | | CAS: | 67469-81-2 | | MF: | C28H35ClN2O | | MW: | 451.05 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 67469-81-2.mol |
| 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Chemical Properties |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | H2O: 20 mg/mL with warming | | form | powder | | color | white |
| 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Usage And Synthesis |
| Uses | A very potent and selective inhibitor of dopamine uptake | | Definition | ChEBI: A hydrochloride salt that is obtained by reaction of 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine with two equivalents of hydrogen chloride. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal memb
anes). | | Biochem/physiol Actions | GBR 12935 inhibits the dopamine and norepinephrine transporters with Kis of 21.5 nM and 225 nM, respectively. It does not inhibit the serotonin transporter (Ki = 6.5 mM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450. |
| 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials |
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