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| POLYGODIAL Basic information |
| Product Name: | POLYGODIAL | | Synonyms: | (-)-Tadeonal;1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (1R-(1alpha,4abeta,8aalpha))-;1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (2R,4as,8as)-;1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-;1,4,4A,5,6,7,8,8A-Octahydro-5,5,8A-trimethyl-1,2-naphthalenedicarboxaldehyde;Drim-7-ene-11,12-dial;Poligodial;(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde | | CAS: | 6754-20-7 | | MF: | C15H22O2 | | MW: | 234.33 | | EINECS: | | Product Categories: | Miscellaneous Natural Products | | Mol File: | 6754-20-7.mol |
| POLYGODIAL Chemical Properties |
| Melting point | 57° (Barnes, Loder) | | alpha | D24 -131° (c = 0.96 in ethanol) | | Boiling point | 330.7±35.0 °C(Predicted) | | density | 1.084±0.06 g/cm3(Predicted) | | RTECS | QJ2850000 | | storage temp. | -20°C | | solubility | DMSO: soluble20mg/mL, clear | | form | powder | | color | white to beige | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| Risk Statements | 52/53 | | Safety Statements | 61 | | WGK Germany | 3 |
| POLYGODIAL Usage And Synthesis |
| Description | Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1?A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2 | | Uses | Polygodial is a naturally occurring antifungal and antinociceptive. | | Biochem/physiol Actions | Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae. | | References | 1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136
2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590 |
| POLYGODIAL Preparation Products And Raw materials |
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