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| TETANUS TOXIN Basic information |
| TETANUS TOXIN Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: soluble |
| TETANUS TOXIN Usage And Synthesis |
| Uses | Tetanus toxin is the tetanus toxin produced by the anaerobic bacillus?Clostridium tetani. | | Uses | Tetanus toxin from Clostridium tetani has been used as the exocytosis inhibitor/Golgi-dependent secretion to examine whether secretory carrier membrane protein (SCAMP5) stimulated α-synuclein secretion via the conventional Golgi-dependent pathway. It has also been used in peripheral blood mononuclear cells (PBMCs) culture for?T?cell?proliferation screening. | | General Description | Tetanus toxin is also known as tetanospasmin. It is a 150-kDa protein, produced by Clostridium tetani. This protein consists of a light and a heavy chain. | | Biochem/physiol Actions | Binds to polysialogangliosides acceptors on surface of all peripheral presynaptic nerve terminals. Internalized by receptor-mediated endocytosis and carried to spinal cord and brain by transsynaptic retrograde transport. Blocks the release of glycine from inhibitory interneurons of the spinal cord. Cleaves synaptobrevin (VAMP-2), and blocks synaptic vesicle exocytosis in vivo. |
| TETANUS TOXIN Preparation Products And Raw materials |
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