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| L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Basic information |
| Product Name: | L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE | | Synonyms: | H-GLU(PNA)-OH HCL;L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE;L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE;GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;l-glutamic acid γ-(p-nitroanilide) hydrochloride;L-Glutamic acid g-(p-nitroanilide) hydrochloride;L-y-GLUTAMYL-p-NITROANILIDE HYDROCHLORIDE extrapure | | CAS: | 67953-08-6 | | MF: | C11H14ClN3O5 | | MW: | 303.7 | | EINECS: | 267-944-5 | | Product Categories: | | Mol File: | 67953-08-6.mol |
| L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Chemical Properties |
| L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Usage And Synthesis |
| Description | L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2?Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3 | | Uses | L-Glutamic acid gamma-(p-nitroanilide) is used in methods of treating cancers having a deregulated NRF2/KEAP1 pathway. | | References | 1) Meister?et al. (1981),?γ-Glutamyl transpeptidase; Methods Enzymol.,?77?237
2) Esslinger?et al. (2005),?N-gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site; Bioorg. Med. Chem.,?13?1111
3) Nicklin?et al. (2012),?Bidirectional Transport of Amino Acid Regulates mTOR and Autophagy; Cell,?136?521 |
| L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Preparation Products And Raw materials |
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