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| Product Name: | GW4869 | | Synonyms: | N-SMase Inhibitor, GW4869 - CAS 6823-69-4 - Calbiochem;CS-2410;N-SMase Inhibitor;2-PropenaMide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-iMidazol-2-yl)phenyl]-, hydrochloride (1:2);4',4''-Di-2-imidazolin-2-yl-p-benzenediacrylanilide dihydrochloride;GW 4869 (hydrochloride hydrate);GW4869/GW-4869;GW4869 dihydrochloride | | CAS: | 6823-69-4 | | MF: | C30H29ClN6O2 | | MW: | 541.05 | | EINECS: | | Product Categories: | API;A cell-permeable, symmetrical dihydroimidazolo-amide compound that acts as a potent, specific, non-competitive inhibitor of N-SMase. | | Mol File: | 6823-69-4.mol |
| GW4869 Chemical Properties |
| Melting point | >300 °C | | storage temp. | 2-8°C | | solubility | DMSO: soluble0.2mg/mL | | form | powder | | color | light yellow to yellow |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 2933299090 |
| GW4869 Usage And Synthesis |
| Uses | GW4869 has been used:- as an inhibitor of neutral sphingomyelinase and exosome biogenesis
- to analyse the effects of arsenic trioxide (ATO) treatment for hepatoma carcinoma HCCLM3 cells on ceramide production
- to determine the contributions of p75 neurotrophin receptor (p75NTR) and tropomyosin receptor kinase A (TrkA)- coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats
| | General Description | GW4869 is a commonly used pharmacological agent, which inhibits exosome generation. It blocks ceramide-mediated inward budding of multivesicular bodies (MVBs) and the release of mature exosomes from MVBs. GW4869 exhibits cytotoxicity to phosphatidylserine-expressing myeloma cells. It inhibits the secretion of IFN (interferon)-α by plasmacytoid dendritic cells?(pDCs). | | Biochem/physiol Actions | A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase) |
| GW4869 Preparation Products And Raw materials |
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