TRIETHYL 2-PHOSPHONOBUTYRATE

TRIETHYL 2-PHOSPHONOBUTYRATE
  • CAS No.:17145-91-4

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
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TRIETHYL 2-PHOSPHONOBUTYRATE Basic information
Product Name:TRIETHYL 2-PHOSPHONOBUTYRATE
Synonyms:2-PHOSPHONOBUTYRIC ACID TRIETHYL ESTER;Diethyl 1-(ethoxycarbonyl)propanephosphonate~2-Phosphonobutyric acid triethyl ester;diethyl 1-(ethoxycarbonyl)propanephosphonate;Diethyl[1-(ethoxycarbonyl)propyl]phosphonate, 98 %;Ethyl 2-(diethoxyphosphoryl)butanoate;alpha-Diethylphosphonobutanoic acid ethyl ester;Ethyl 2-(diethoxyphosphinyl)butanoate;Ethyl 2-(diethylphosphono)butyrate
CAS:17145-91-4
MF:C10H21O5P
MW:252.24
EINECS:627-866-8
Product Categories:C-C Bond Formation;Horner-Wadsworth-Emmons Reagents;Olefination
Mol File:17145-91-4.mol
TRIETHYL 2-PHOSPHONOBUTYRATE Chemical Properties
Boiling point 152-154 °C14 mm Hg(lit.)
density 1.064 g/mL at 25 °C(lit.)
refractive index n20/D 1.432(lit.)
Fp >230 °F
storage temp. Sealed in dry,Room Temperature
form Liquid
Specific Gravity1.064
color Clear colorless
Water Solubility Not miscible or difficult to mix with water.
BRN 1789280
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 29310099
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
TRIETHYL 2-PHOSPHONOBUTYRATE Usage And Synthesis
Chemical Propertiesclear colorless liquid
UsesReactant used for preparation of furospinosulin-1 and analogs as hypoxia-selective antitumor agents, Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer?s drugs, phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents, PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists, notch-sparing γ-secretase inhibitors derived from PPAR agonist library and plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis.
UsesReactant for preparation of:
  • Furospinosulin-1 and analogs as hypoxia-selective antitumor agents
  • Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer′s drugs
  • Phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents
  • PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists
  • Notch-sparing γ-secretase inhibitors derived from PPAR agonist library
  • Plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis
  • Quinone/naphthoquinone-substituted propenoic acids as inhibitors of cell growth and redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor 1 (Ape1/Ref-1)
  • α-alkenyl cyclic ethers by asymmetric dehydrative cyclization of ω-hydroxy allyl alcohols catalyzed by Ru complexes of axially chiral naphthylpyridinecarboxylates
  • Branched phosphonoethoxyethyl purines as new acyclic nucleoside phosphonates which inhibit Plasmodium falciparum (malarial parasite) hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT)
  • Phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists as candidate drugs for treatment of altered metabolic homeostasis
TRIETHYL 2-PHOSPHONOBUTYRATE Preparation Products And Raw materials

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