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| N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE Basic information |
| Product Name: | N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE | | Synonyms: | N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE;N-(METHOXYSUCCINYL)-L-ALANYL-L-ALANYL-L-PROLYL-L-VALINE 4-NITROANILIDE;ELASTASE SUBSTRATE I, COLORIMETRIC;MEO-SUC-ALA-ALA-PRO-VAL-PARANITROANILIDE;MEOSUC-ALA-ALA-PRO-VAL-PNA;METHOXYSUCCINYL-ALA-ALA-PRO-VAL-P-NITROANILIDE;METHOXYSUCCINYL-ALA-ALA-PRO-VAL-P-NITROANILIDE, METHANOL ADDUCT;L-Valinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)- | | CAS: | 70967-90-7 | | MF: | C27H38N6O9 | | MW: | 590.63 | | EINECS: | 232-670-7 | | Product Categories: | | Mol File: | 70967-90-7.mol |
| N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE Chemical Properties |
| Melting point | 203-205°C | | Boiling point | 958.4±65.0 °C(Predicted) | | density | 1.297±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMF: 25 mg/mL, clear, light yellow | | form | Off-white solid | | pka | 13.29±0.20(Predicted) | | color | White to Off-White | | BRN | 6266359 |
| N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE Usage And Synthesis |
| Description | Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens. Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3, but not cathepsin G or chymotrypsin. Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm. | | Uses | N-Methoxysuccinyl-Ala-Ala-Pro-Val p-Nitroanilide is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3 but not cathespin. |
| N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE Preparation Products And Raw materials |
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