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| Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Basic information |
| Product Name: | Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine | | Synonyms: | Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine;CyPPA;N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine;N-Cyclohexyl-N-[2-(3,5-diMethyl-pyrazol-1-yl)-6-Methyl-4-pyriMid;4-PyriMidinaMine, N-cyclohexyl-2-(3,5-diMethyl-1H-pyrazol-1-yl)-6-Methyl-;N-Cyclohexyl-N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amine;N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine;N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl) | | CAS: | 73029-73-9 | | MF: | C16H23N5 | | MW: | 285.39 | | EINECS: | | Product Categories: | | Mol File: | 73029-73-9.mol |
| Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Chemical Properties |
| density | 1.23 | | storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | solid | | color | white |
| Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Usage And Synthesis |
| Uses | CyPPA is a positive SK3/SK2 modulator that reduces the activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methyl phenidate. | | Uses | CyPPA has been used:- to test its inhibitory functionality on melanogenesis
- as an activator of small conductance potassium channel-3 (SK3) in mesenteric artery segments
- in the activation of calcium-activated potassium (SK) channels in murine hippocampal neurons HT-22 cells
| | Biological Activity | Activator of small conductance Ca 2+ -activated K + channels that displays selectivity for SK2 and SK3 channels (EC 50 values are 5.6 and 14 μ M for SK3 and SK2 respectively). Displays no activity at SK1 and IK channels. | | Biochem/physiol Actions | CyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels. |
| Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Preparation Products And Raw materials |
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![Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine](/img/73029-73-9.jpg "Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine")
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