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| FR 900098 MonosodiuM Salt Basic information |
| FR 900098 MonosodiuM Salt Chemical Properties |
| Melting point | 184-186°C | | storage temp. | -20°C | | solubility | H2O: ≥20mg/mL | | form | powder | | color | white to light brown | | Stability: | Hygroscopic |
| FR 900098 MonosodiuM Salt Usage And Synthesis |
| Chemical Properties | Pale Brown Solid | | Uses | The antibiotics Fosmidomycin and FR900098 are members of a unique class of phosphonic acid natural products that inhibit the nonmevalonate pathway for isoprenoid biosynthesis. Both are potent antibacterial and antimalarial compounds. | | Biochem/physiol Actions | 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway). Inhibiton of the enzyme provides alternative to traditional antimalaria therapy. FR-900098 is twice more effective than fosmidomycin against various strains of P. falciparum in vitro and the closely related P. vinckei in mice. |
| FR 900098 MonosodiuM Salt Preparation Products And Raw materials |
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