FR 900098 MonosodiuM Salt

CAS No.：73226-73-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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FR 900098 MonosodiuM Salt Basic information

Product Name:	FR 900098 MonosodiuM Salt
Synonyms:	FR900098 sodium salt (FR 900098);FR 900098 MonosodiuM Salt;P-[3-(AcetylhydroxyaMino)propyl]phosphonic Acid SodiuM Salt;P-[3-(Acetylhydroxyamino)propyl]-phosphonic acid;FR900098 (sodium salt);BRN 2096083;FR00098 (sodium salt)
CAS:	73226-73-0
MF:	C5H11NNaO5P
MW:	219.108071
EINECS:
Product Categories:	Aliphatics;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
Mol File:	73226-73-0.mol

FR 900098 MonosodiuM Salt Chemical Properties

Melting point	184-186°C
storage temp.	-20°C
solubility	H2O: ≥20mg/mL
form	powder
color	white to light brown
Stability:	Hygroscopic

Safety Information

WGK Germany

MSDS Information

FR 900098 MonosodiuM Salt Usage And Synthesis

Chemical Properties	Pale Brown Solid
Uses	The antibiotics Fosmidomycin and FR900098 are members of a unique class of phosphonic acid natural products that inhibit the nonmevalonate pathway for isoprenoid biosynthesis. Both are potent antibacterial and antimalarial compounds.
Biochem/physiol Actions	1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway). Inhibiton of the enzyme provides alternative to traditional antimalaria therapy. FR-900098 is twice more effective than fosmidomycin against various strains of P. falciparum in vitro and the closely related P. vinckei in mice.

FR 900098 MonosodiuM Salt Preparation Products And Raw materials

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