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| Deoxynojirimycin hydrochloride Basic information |
| Deoxynojirimycin hydrochloride Chemical Properties |
| Melting point | 195-196°C | | storage temp. | Inert atmosphere,2-8°C | | solubility | Water (Slightly) | | form | Powder | | color | White | | Water Solubility | Soluble in water at 20mg/ml | | BRN | 3563225 | | Stability: | Hygroscopic | | CAS DataBase Reference | 73285-50-4 |
| Deoxynojirimycin hydrochloride Usage And Synthesis |
| Description | 1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in M. alba (mulberry) leaves and has diverse biological activities. It inhibits the activities of α- and β-glucosidase (IC50s = 35 and 71 μM, respectively). 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells. It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM. 1-DNJ (1-100 μg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells. It improves glucose and insulin tolerance in db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks. | | Chemical Properties | White Crystalline Solid | | Uses | natural chitin synthase inhibitor | | Uses | Deoxynojirimycin inhibits mammalian glucosidase 1. As well, it inhibits intestinal and lysosmal alpha-glucosidases, beta-glucosidase from sweet almonds, pancreatic alpha-amylase and amyloglucosidase. | | Uses | Deoxynojirimycin inhibits mammalian glucosidase 1. As well, it inhibits intestinal and lysosmal alpha-glucosidases, beta-glucosidase from sweet almonds, pancreatic alpha-amylase and amyloglucosidase. | | General Description | Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc3Man9GlcNAc2 in N-linked glycan biosynthesis. | | Biochem/physiol Actions | Product does not compete with ATP. |
| Deoxynojirimycin hydrochloride Preparation Products And Raw materials |
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