Other grades of this product :
| EGFR Inhibitor III Basic information |
| Product Name: | EGFR Inhibitor III | | Synonyms: | EGFR Inhibitor III;EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem;Acetamide, 2-chloro-N-[4-[(4,5-dichloro-2-fluorophenyl)amino]-6-quinazolinyl]- | | CAS: | 733009-42-2 | | MF: | C16H10Cl3FN4O | | MW: | 399.63 | | EINECS: | | Product Categories: | | Mol File: | 733009-42-2.mol |
| EGFR Inhibitor III Chemical Properties |
| Melting point | >300 °C | | Boiling point | 566.7±50.0 °C(Predicted) | | density | 1.607±0.06 g/cm3(Predicted) | | storage temp. | -20C | | form | Yellow solid | | pka | 11.18±0.43(Predicted) |
| EGFR Inhibitor III Usage And Synthesis |
| Uses | EGFR Inhibitor III is which inhibits EGFR- kinase activity, blocking phosphorylation. | | General Description | A cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 μM and 1.1 μM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation. | | Biochem/physiol Actions | Target IC50: 0.7 μM and 1.1 μM suppressesing leiomyoma and myometrical cell proliferation, respectively |
| EGFR Inhibitor III Preparation Products And Raw materials |
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