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| LEUKOTRIENE D4 Basic information |
| Product Name: | LEUKOTRIENE D4 | | Synonyms: | LEUKOTRIENE D4;(r-(r*,s*-(e,e,z,z)))-inyl);YEESKJGWJFYOOK-IJHYULJSSA-N;glycine,n-(s-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-l-cyste;leukotriened;leukotriened(sub4);(5S,6R,7E,9E,11E,14E)-6-[2-amino-2-(carboxymethylcarbamoyl)ethyl]sulfanyl-5-hydroxy-icosa-7,9,11,14-tetraenoic acid;LEUKOTRIENE D4 (ETHANOL SOLUTION) | | CAS: | 73836-78-9 | | MF: | C25H40N2O6S | | MW: | 496.66 | | EINECS: | | Product Categories: | Arachidonic Acid Cascade;Fatty Acids;Leukotrienes;LeukotrienesLipids;Lipids in Cell Signaling | | Mol File: | 73836-78-9.mol |
| LEUKOTRIENE D4 Chemical Properties |
| Boiling point | 785.8±60.0 °C(Predicted) | | density | 1.162±0.06 g/cm3(Predicted) | | Fp | 9℃ | | storage temp. | -70°C | | form | Liquid. | | pka | 3.03±0.10(Predicted) |
| LEUKOTRIENE D4 Usage And Synthesis |
| Description | Leukotriene D4 (LTD4) is an active metabolite of LTC4 (Item Nos. 20210 | 10007241) and a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is formed via metabolism of LTC4 by γ-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal spirals. In vivo, LTD4 increases insufflation pressure, a marker of bronchoconstriction, in anesthetized guinea pigs by 100% when administered at a dose of 89 pmol per animal. It also increases vascular permeability in guinea pig skin when administered intradermally at a dose of 0.1 pmol per animal. | | Uses | LTD4 (Leukotriene D4) is a member of the leukotriene family shown to be a potent contractor of smooth muscle. | | Definition | ChEBI: A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at
position 6 (6R). | | Biochem/physiol Actions | Slow reacting substance of anaphylaxis (SRS-A). Potent bronchoconstrictor and mediator of asthmatic and inflammatory processes. Increases cytosolic free Ca2+ in epithelial cells. |
| LEUKOTRIENE D4 Preparation Products And Raw materials |
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