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| L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Basic information | | Description |
| Product Name: | L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid | | Synonyms: | (S)-TIC;(S)-N-tert-1,2,3,4-tetrahydroisoquinoline -3-carboxamide;L-1,2,3,4-Tetrahydro;4-Tetrahydro-3-Isoquinolinecarboxylic acid;[S]-1,2,3,4-Tetrahydro-3-Isoquinolingcarboxylic Acid;(S)-1, 2, 3, 4-tetrahydro-3-isoquinolinecarboxylic acid (for Quinapril);L-1,2,3,4-Tetrahydroisoquinoline-3-CarboxylicAcid98%;(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYLESTHER | | CAS: | 74163-81-8 | | MF: | C10H11NO2 | | MW: | 177.2 | | EINECS: | 616-058-0 | | Product Categories: | Carboxylic Acids;(intermediate of quinapril);Amino Acids;Carboxylic Acids;Quinolines, Isoquinolines & Quinoxalines;chiral;IsoquinolinesPeptide Synthesis;Chiral Building Blocks;Heterocyclic Building Blocks;Others;Unnatural Amino Acid Derivatives;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Quinolines, Isoquinolines & Quinoxalines;Peptide Synthesis;a-amino;Pharmaceuticals;Halogenated Heterocycles ,Thiophenes ,Thiazolines/Thiazolidines | | Mol File: | 74163-81-8.mol |
| L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Chemical Properties |
| Melting point | >300 °C(lit.) | | alpha | -157.4 º (24 ºC) | | Boiling point | 309.12°C (rough estimate) | | density | 1.1607 (rough estimate) | | refractive index | -166 ° (C=1, 1mol/L NaOH) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | pka | 2.21±0.20(Predicted) | | form | powder to crystal | | color | White to Almost white | | optical activity | [α]20/D 168°, c = 1.8 in 1.4 M NaOH | | BRN | 4842199 | | InChIKey | BWKMGYQJPOAASG-VIFPVBQESA-N | | CAS DataBase Reference | 74163-81-8(CAS DataBase Reference) |
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ACROS
| English |
| L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Usage And Synthesis |
| Description | (S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a quinoline derivative, which is used as an intermediate in the synthesis of quinapril. Quinapril, a product developed by Pfizer, was approved by the US FDA in 1991 for the treatment of hypertension, congestive heart failure and angioedema. | | Chemical Properties | white to light yellow crystal powde | | Uses | Quinapril intermediate. | | Uses | (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Quinapril EP Impurity A) is a Quinapril intermediate. |
| L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Preparation Products And Raw materials |
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