N-(Chloromethyl)phthalimide

CAS No.：17564-64-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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N-(Chloromethyl)phthalimide Basic information

Product Name:	N-(Chloromethyl)phthalimide
Synonyms:	AKOS BBS-00000871;2-(CHLOROMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE;TIMTEC-BB SBB000346;N-(CHLOROMETHYL)PHTHALIMIDE;1H-Isoindole-1,3(2H)-dione, 2-(chloromethyl)-;2-(chloromethyl)-1h-isoindole-3(2h)-dione;Chloromethylphthalimide;N-Chloromethyltrimellitimide
CAS:	17564-64-6
MF:	C9H6ClNO2
MW:	195.6
EINECS:	241-541-4
Product Categories:	API Intermediate;Carbonyl Compounds;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides;Cyclic Imides;Organic Building Blocks;Analytical Chemistry;Carboxyl Group Labeling Reagents for HPLC;HPLC Labeling Reagents;UV Detection (HPLC Labeling Reagents)
Mol File:	17564-64-6.mol

N-(Chloromethyl)phthalimide Chemical Properties

Melting point	131-135 °C (lit.)
Boiling point	305.2±25.0 °C(Predicted)
density	1.3228 (rough estimate)
refractive index	1.5790 (estimate)
storage temp.	2-8°C
solubility	chloroform: soluble50mg/mL
pka	-2.63±0.20(Predicted)
form	powder to crystal
color	White to Almost white
Water Solubility	slightly soluble
BRN	140942
CAS DataBase Reference	17564-64-6(CAS DataBase Reference)
NIST Chemistry Reference	N-(chloromethyl)phthalimide(17564-64-6)
EPA Substance Registry System	1H-Isoindole-1,3(2H)-dione, 2-(chloromethyl)- (17564-64-6)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-52/53-43-22
Safety Statements	26-36-37/39-61-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
F	9-21
TSCA	Yes
HS Code	29251995

MSDS Information

Provider	Language
N-(Chloromethyl)phthalimide	English
SigmaAldrich	English
ACROS	English
ALFA	English

N-(Chloromethyl)phthalimide Usage And Synthesis

Chemical Properties	white crystalline powder
Uses	It is used as an agrochemical and medicine intermediates and is used in organic synthesis. Microporous membranes prepared from chemically modified polysulfone, which is a derivative of this compound have better streaming potential.
Purification Methods	Purify the imide by recrystallisation from EtOAc or CCl4 or via the 1:1 complex with pyridine [Sakellarios J Am Chem Soc 70 2822 1948, B.hme et al. Chem Ber 92 1258 1959]. [Beilstein 21/10 V 372.]

N-(Chloromethyl)phthalimide Preparation Products And Raw materials

Raw materials	Toluene-->Phthalimide
Preparation Products	BIS(DIETHYLAMINO)CHLOROPHOSPHINE

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