Other grades of this product :
| CID 5951923 Basic information |
| Product Name: | CID 5951923 | | Synonyms: | CID 5951923;3-(3-Nitrophenyl)-2-propenoic Acid 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)aMino]-2-oxoethyl Ester;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-methyl ester;[2-[(1,1-Dioxothiolan-3-yl)-methylamino]-2-oxoethyl] (E)-3-(3-nitrophenyl)prop-2-enoate;AC1NZ6UQ;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-me;KLF5 Inhibitor, CID 5951923;KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem | | CAS: | 749872-43-3 | | MF: | C16H18N2O7S | | MW: | 382.39 | | EINECS: | | Product Categories: | Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 749872-43-3.mol |
| CID 5951923 Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO: soluble10mg/mL (clear solution) | | form | powder | | color | white to beige |
| CID 5951923 Usage And Synthesis |
| Uses | This compound acts as a KLF-5 expression inhibitor. which in turn reduces proliferation cell rates in colorectal cancer cells in humans. | | Uses | This compound acts as a KLF-5 expression inhibitor. which in turn reduces proliferation cell rates in colorectal cancer cells in humans. | | General Description | A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 μM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182. |
| CID 5951923 Preparation Products And Raw materials |
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