PENTAFLUOROBENZYL BROMIDE

PENTAFLUOROBENZYL BROMIDE
  • CAS No.:1765-40-8

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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PENTAFLUOROBENZYL BROMIDE Basic information
Product Name:PENTAFLUOROBENZYL BROMIDE
Synonyms:1-(Bromomethyl)-2,3,4,5,6-pentafluorobenzene;1-Bromomethylpentafluorobenzene;PFBBR;PENTAFLUOROBENZYL BROMIDE;PENTAFLUOROBROMOMETHYL BENZENE;(BROMOMETHYL)PENTAFLUOROBENZENE;Toluene, alpha-bromo-2,3,4,5,6-pentafluoro-;1-(Bromomethyl)-2,3,4,5,6-pentafluorobenzene, alpha-Bromo-2,3,4,5,6-pentafluorotoluene
CAS:1765-40-8
MF:C7H2BrF5
MW:260.99
EINECS:217-182-4
Product Categories:Alkylation Reagent;organofluorine compounds;Aromatic Halides (substituted);Analytical Chemistry;Boronic Acid, etc. (GC Derivatizing Reagents);GC Derivatizing Reagents
Mol File:1765-40-8.mol
PENTAFLUOROBENZYL BROMIDE Chemical Properties
Melting point 19-20 °C(lit.)
Boiling point 174-175 °C(lit.)
density 1.728 g/mL at 25 °C(lit.)
refractive index n20/D 1.471(lit.)
Fp 181 °F
storage temp. Store below +30°C.
form Liquid
Specific Gravity1.728
color Clear colorless to yellow
Water Solubility Hydrolyzes in water.
Sensitive Lachrymatory
BRN 647808
CAS DataBase Reference1765-40-8(CAS DataBase Reference)
NIST Chemistry ReferenceBenzene, (bromomethyl)pentafluoro-(1765-40-8)
Safety Information
Hazard Codes C,Xi
Risk Statements 34-36/37/38-36/37-22
Safety Statements 26-36/37/39-45-23-27
RIDADR UN 3265 8/PG 2
WGK Germany 3
F 19
Hazard Note Irritant/Lachrymatory
HazardClass 8
PackingGroup II
HS Code 29039990
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
PENTAFLUOROBENZYL BROMIDE Usage And Synthesis
Chemical PropertiesCLEAR COLOURLESS TO YELLOWISH LIQUID
UsesPentafluorobenzyl bromide (PFB-Br) is an alkylating reagent which can be used to modify hydroxyl groups, carboxyl groups, sulfhydryl groups, and amines.PFB-Br can also be used to measure nitrite and peroxynitrite.It is a versatile reagent.
Uses2,3,4,5,6-Pentafluorobenzyl bromide is used as a reagent for derivatization of alcohols, carboxylic acids, sulfonamides for GC and polyfunctional thiols. It is used for the preparation of pentafluorobenzyl esters of organic acids for determination by capillary and GC. It is also used to derivatize N-7-substituted guanine adducts of DNA for determination by GC-electron capture-MS.
UsesLearn more in the Product Information
General DescriptionPentafluorobenzyl bromide (PFB-Br) is a derivatization reagent. Excess reagent may be removed by reaction with an aminophenol. It is an alkylation reagent suitable for electron capture detector (ECD) detection. It is also a lachrymator.

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