Other grades of this product :
| (+/-)-THIOPENTAL Basic information |
| Product Name: | (+/-)-THIOPENTAL | | Synonyms: | 5-ETHYL-5-[1-METHYLBUTYL]-2-THIOBARBITURIC ACID;5-ETHYL-5-PENTAN-2-YL-2-SULFANYL-1H-PYRIMIDINE-4,6-DIONE;5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione;(±)thiopental solution;2-Thio-5-ethyl-5-sec-pentylbarbituric acid;4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- (9CI);Barbituric acid, 5-ethyl-5-(1-methylbutyl)-2-thio- (8CI);PENTOTHAL ACID | | CAS: | 76-75-5 | | MF: | C11H18N2O2S | | MW: | 242.34 | | EINECS: | 200-984-3 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 76-75-5.mol |
| (+/-)-THIOPENTAL Chemical Properties |
| (+/-)-THIOPENTAL Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Originator | Pentothal,Abbott | | Uses | A thio-derivative of Barbituric acid. Controlled substance (depressant). Anesthetic | | Manufacturing Process | 130 g of ethyl (1-methylbutyl) malonic ester is added to a concentrated
solution of sodium ethylate prepared from 34 g of sodium in absolute alcohol;
with stirring, 60 g of finely divided thiourea is added, and, the mixture
refluxed for 10 hours. Most or all of the solvent is evaporated and the residual
mass is dissolved in cold water. The barbituric acid derivative so formed is
precipitated by the addition of dilute hydrochloric acid. It may be 1 purified by
solution in dilute ammonium hydroxide solution and precipitated by carbon
dioxide, followed by recrystallization from 95% alcohol. The ethyl (1-
methylbutyl)thiobarbituric acid so obtained is a white crystalline solid, melting
at 158-159°C and readily forming salts with alkalies. | | Brand name | Thiopental is BAN. | | Therapeutic Function | Narcotic analgesic, Anesthetic | | Safety Profile | Poison by intraperitoneal, intravenous, and rectal routes. Moderately toxic by ingestion. An experimental teratogen. Human mutation data reported. A short-acting intravenous anesthetic. When heated to decomposition it emits very toxic fumes of NOx and SOx |
| (+/-)-THIOPENTAL Preparation Products And Raw materials |
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