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| TRIACSIN C Basic information |
| Product Name: | TRIACSIN C | | Synonyms: | TRIACSIN C;WS1228A;2,4,7-UNDECATRIENAL NITROSOHYDRAZONE;2E, 4E, 7E-UNDECATRIENE-1-TRIAZENE;Triacsincapprox.90%;2,4,7-Undecatrienal;triacsin c from streptomyces sp.;2E,4E,7E-undecatriene-1-triazine | | CAS: | 76896-80-5 | | MF: | C11H17N3O | | MW: | 207.27 | | EINECS: | 616-408-2 | | Product Categories: | antibiotic | | Mol File: | 76896-80-5.mol |
| TRIACSIN C Chemical Properties |
| Boiling point | 320.7±45.0 °C(Predicted) | | density | 0.94±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | methanol: soluble4.90 - 5.10 mg/mL, clear (Pale yellow to yellow) | | form | Liquid. In DMSO. | | pka | -0.10±0.70(Predicted) | | color | clear (Pale yellow to yellow) Solution in DMSO | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions further diluted with DMSO may be stored at -20° for up to 2 months. |
| WGK Germany | 3 | | HS Code | 29299090 |
| TRIACSIN C Usage And Synthesis |
| Description | Triacsin C (76896-80-5) is a long-chain fatty acyl CoA synthetase inhibitor (IC50=3.6-8.7 μM).1?Inhibits mouse macrophage-derived foam cell formation2 and displays anti-atherosclerotic activity3. Cell permeable. | | Chemical Properties | Solid | | Uses | Triacsin, a fatty acyl CoA synthetase inhibitor, reduces myocardial infarct size, attenuates loss of post-reperfusion cardiac function, increases intravascular nitric oxide (NO) concentration, and inhibits leukocyte recruitment. Triacsin C analogs can also be used as potential antivirals against rotavirus infections. | | General Description | Triacsin C belongs to a family of fungal metabolites all having an 11-carbon alkenyl chain with a common N-hydroxytriazene moiety at the terminus. | | Biochem/physiol Actions | Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism. | | References | 1) Hartman et al. (1989), Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase; Prostaglandins, 37 655
2) Namatame et al. (1999), Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C; J. Biochem, 125 319
3) Matsuda et al. (2008), Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor; J. Antibiot. (Tokyo), 61 318 |
| TRIACSIN C Preparation Products And Raw materials |
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