2-PHENYLBUTYRONITRILE

2-PHENYLBUTYRONITRILE
  • CAS No.:769-68-6
Other grades of this product :
2-PHENYLBUTYRONITRILE Basic information
Product Name:2-PHENYLBUTYRONITRILE
Synonyms:.alpha.-ethyl-Benzeneacetonitrile;alpha-ethyl-benzeneacetonitril;Benzeneacetonitrile,alpha.-ethyl-;Butanenitrile, 2-phenyl;-Phenylbutyronitrile;(2S)-2-phenylbutanenitrile;DL-2-phenylbutyronitrile;a-Ethylphenylacetonitrile
CAS:769-68-6
MF:C10H11N
MW:145.2
EINECS:212-213-8
Product Categories:Building Blocks;C10 to C27;Chemical Synthesis;Cyanides/Nitriles;Nitrogen Compounds;Organic Building Blocks
Mol File:769-68-6.mol
2-PHENYLBUTYRONITRILE Chemical Properties
Boiling point 114-115 °C15 mm Hg(lit.)
density 0.974 g/mL at 25 °C(lit.)
refractive index n20/D 1.5086(lit.)
Fp 221 °F
storage temp. Refrigerator, under inert atmosphere
solubility Chloroform (Slightly), Methanol (Slightly)
form Oil
color Colourless
Specific Gravity0.974
CAS DataBase Reference769-68-6(CAS DataBase Reference)
EPA Substance Registry SystemBenzeneacetonitrile, .alpha.-ethyl- (769-68-6)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 36/37
RIDADR 3276
WGK Germany 3
TSCA Yes
HazardClass 6.1
PackingGroup III
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
2-PHENYLBUTYRONITRILE Usage And Synthesis
Uses2-Phenylbutyronitrile is an intermediate in synthesizing rac-Glutethimide (G598150), a hypnotic sedative which was once used to treat insomnia. When taken with codeine, it has an intense euphoric effect on the subject due to the body’s increased ability to convert codeine to morphine.
Synthesis Reference(s)Tetrahedron Letters, 22, p. 4107, 1981 DOI: 10.1016/S0040-4039(01)82078-5
2-PHENYLBUTYRONITRILE Preparation Products And Raw materials
Raw materialsBromoethane
Preparation Products2-Phenylbutyryl chloride-->Aminoglutethimide

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